Reducing IAPP Aggregation with Mitochondrial Humanin Peptides; Results from Simulations and Experiments
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چکیده
منابع مشابه
Myricetin Inhibits Islet Amyloid Polypeptide (IAPP) Aggregation and Rescues Living Mammalian Cells from IAPP Toxicity
The aggregation of the amyloidogenic polypeptide IAPP (Islet Amyloid Polypeptide, amylin) is believed to play a direct role in the death of pancreatic β-islet cells in type II diabetes. Preventing the initial aggregation event of IAPP is one strategy for slowing, and possibly preventing, the progression of this disease. Here, we investigate myricetin's potential as an inhibitor of IAPP aggregat...
متن کاملThe Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction
PURPOSE To investigate the expression of humanin (HN) in human retinal pigment epithelial (hRPE) cells and its effect on oxidative stress-induced cell death, mitochondrial bioenergetics, and senescence. METHODS Humanin localization in RPE cells and polarized RPE monolayers was assessed by confocal microscopy. Human RPE cells were treated with 150 μM tert-Butyl hydroperoxide (tBH) in the absen...
متن کاملFollowing the aggregation of amyloid-forming peptides by computer simulations.
There is experimental evidence suggesting that the toxicity of neurodegenerative diseases such as Alzheimer's disease may result from the soluble intermediate oligomers. It is therefore important to characterize extensively the early steps of oligomer formation at atomic level. As these structures are metastable and short lived, experimental data are difficult to obtain and they must be complem...
متن کاملStudies of IAPP from Type-II Diabetes and the M2 Proton Channel from Influenza with Novel Methods for Molecular Dynamics Simulations of Membrane Peptides
Membrane proteins comprise approximately 30% of proteins found in vivo, but remain a challenging topic for study with traditional Biophysical techniques. We were interested in studying the M2 Proton Channel from the Influenza Virus and Islet Amyloid Polypeptide (IAPP), the amyloid peptide found associated with Type-II Diabetes Mellitus. Studies of these two proteins are crucial for the understa...
متن کامل[Humanin and its derivatives as peptides with potential antiapoptotic and confirmed neuroprotective activities].
Humanin (HN) is a newly discovered 24-amino acid peptide, which may suppress neuronal cell death. HN cDNA includes the open reading frame (HN-ORF) of 75 bases, located 950 bases downstream of the 5' end of the HN cDNA. It was demonstrated that HN cDNA is 99% identical with mitochondrial DNA (mtDNA) sequence. HN homologues have been identified as expressed sequence tags (ESTs) in rat and nematod...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2016
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2015.11.990